Beta
ManageSearchChatDiscover
70026

EVALUATION OF IBUPROFEN-CELLULOSIC POLYMERS SUSTAINED RELEASE TABLETS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Ibuprofen sustained release tabletse were formulated using wet granulation technique and cellulosic polymers as granulating agents including ethyl cellulose 20, hydroxypropyl methyl cellulose (pharmacoat 606) and hydroxypropyl methyl cellulose phthalate (HP 55 F). The effect of tablet excipients including Avicel PH 102, Lactose, Emcompress and Emedex on the release rate of ibuprofen from the prepared tablets was also investigated using shift dissolution method. It was found that among the formulated ibuprofen sustained release tablets, those tablets granulated with 3% w/v ethyl cellulose 20 and containing 23% Emcompress as an excipient were proved to be superior for ibuprofen sustained release. Higher Avicel PH 102 concentration (39 and 40% w/w) was found to enhance the release. Comparing the effect of 1% w/v of the investigated cellulosic polymers on ibuprofen retardation, it was found to be in the following order: ethyl cellulose 20 > HP 55 F > pharmacoat 606. Various kinetic models including zero order, first order and Higuchi equation were applied to explain the release mechanism from the prepared tablets. It was found that the best fit with the highest correlation coefficient was achieved with the zero-order equation.

DOI

10.21608/bfsa.1993.70026

Authors

First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Stamm

MiddleName

-

Affiliation

Faculty of Pharmacy, Louis Pasteur University, France

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Abdel Rahman

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Samy

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

16

Article Issue

1

Related Issue

10639

Issue Date

1993-06-01

Receive Date

1992-07-07

Publish Date

1993-06-30

Page Start

25

Page End

35

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 1_Pages 25-35.pdf

PDF . 663.2kB

Link

https://bpsa.journals.ekb.eg/article_70026.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=70026

Order

3

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EVALUATION OF IBUPROFEN-CELLULOSIC POLYMERS SUSTAINED RELEASE TABLETS

Details

Type

Article

Created At

22 Jan 2023