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70021

ACCELERATED STABILITY TESTING OF IBUPROFEN-EUDRAGIT RSPM SUSTAINED RELEASE TABLETS USING 1H-NMR, HPLC AND TLC

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Last updated: 25 Dec 2024

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Abstract

Ibuprofen-Eudragit RSPM sustained release tablets, already have been formulated, were subjected to accelerated stability testing for 6 months at 25, 37 and 45°C.The tablets were stored in firmly closed glass bottles in order to eliminate the effect of humidity, a condition simulating the actual shelf storage. The drug content of the stored tablets was evaluated using 1H-NMR, HPLC and TLC techniques in order to investigate the effect of temperature on ibuprofen stability. A small reduction (2-4 % w/w) in the drug content was detected in the tablets stored at 37 and 45°C for 6 months using 1H-NMR and HPLC techniques. The decomposition of ibuprofen in the preformulated tablets was found to be first order reaction kinetics. It was concluded that the expiry date of ibuprofen in the formulated sustained release tablets is up to 3 years. Thus this formulation could be considered as a convenient pharmaceutical formulation of ibuprofen.

DOI

10.21608/bfsa.1993.70021

Authors

First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Stamm

MiddleName

-

Affiliation

Faculty of Pharmacy, Louis Pasteur University, France

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Abdel Rahman

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Samy

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

16

Article Issue

1

Related Issue

10639

Issue Date

1993-06-01

Receive Date

1992-06-02

Publish Date

1993-06-30

Page Start

1

Page End

11

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 1_Pages 1-11.pdf

PDF . 559.8kB

Link

https://bpsa.journals.ekb.eg/article_70021.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=70021

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ACCELERATED STABILITY TESTING OF IBUPROFEN-EUDRAGIT RSPM SUSTAINED RELEASE TABLETS USING 1H-NMR, HPLC AND TLC

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Article

Created At

22 Jan 2023