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69802

EFFECT OF FORMULATION VARIABLES OF MULTIPLE EMULSION ON THE STABILITY AND ANTITREMOR ACTIVITY OF CHLORPHENOXAMINE HYDROCHLORIDE

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Last updated: 04 Jan 2025

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Abstract

W/O/W multiple emulsion formulations of chlorphenoxamine hydrochloride were prepared. The results of dissolution indicate that the release of the drug from w/o/w multiple emulsion was significantly sustained.. The incorporation of the additives into the external aqueous phase of w/o/w multiple emulsions based on liquid paraffin increased the release of the drug in the following order: sodium chloride >' Polyvinyl alcohol > hydroxypropyl methylcellulose > polyvinylpyrrolidone.  Stability studies of differentemulsion samples were conducted at various temperatures and, evaluated by using the conductivity method. The obtained data indicated that the emulsions were stable during the storage for 3 months at 25°C. The formula (Fm) of the multiple emulsion which contained castor oil with Span 60 possessed a more efficient prolonged antitremor effect and lowered of spontaneous locomotor activity (SLMA) in mice than that of the drug solution. The statistical analysis also revealed that this formula produced a greater sedative effect compared with that of the drug solution.

DOI

10.21608/bfsa.1994.69802

Authors

First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

I.

Last Name

Samy

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

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Orcid

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First Name

M.

Last Name

Abdel-Rahman

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Volume

17

Article Issue

2

Related Issue

10609

Issue Date

1994-12-01

Receive Date

1994-10-09

Publish Date

1994-12-31

Page Start

165

Page End

176

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 2_Pages 165-176.pdf

PDF . 780.3kB

Link

https://bpsa.journals.ekb.eg/article_69802.html

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https://bpsa.journals.ekb.eg/service?article_code=69802

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF FORMULATION VARIABLES OF MULTIPLE EMULSION ON THE STABILITY AND ANTITREMOR ACTIVITY OF CHLORPHENOXAMINE HYDROCHLORIDE

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Article

Created At

22 Jan 2023