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EFFECTS OF POROUS SILICA AS DRUG CARRIER ON THE FORMULATION OF EFFERVESCENT NYSTATIN VAGINAL TABLETS

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Last updated: 25 Dec 2024

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Abstract

Nystatin was loaded into porous silica by solvent deposition technique. The physical and loaded drug mixtures were examined by DSC and powder X-ray diffractometry.  The stability of the drug at different relative humidities at 25° in these systems was evaluated measuring the antimycotic effectiveness. The in-vitro dissolution of the drug from loaded mixtures was studied. The loaded mixtures were formulated into effervescent vaginal tablets. Physical characteristics and dissolution behavior of the prepared effervescent vaginal tablets were evaluated according to B.P. 1993 limits. DSC and powder X-ray diffraction results revealed that the drug was changed from crystalline to amorphous state depending on drug to carrier ratio. The drug was stable and retained its activity in loaded mixtures stored at 0 % relative humidity for 2 months at 25°. Transformation of the drug to the amorphous state in the loaded mixtures lead to enhancement of drug dissolution. The prepared effervescent vaginal tablets complied with the standard requirements of uniformity of weight, drug content, disintegration time, dissolution, hardness and friability tests.

DOI

10.21608/bfsa.1994.69800

Authors

First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Ali

MiddleName

S.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

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Orcid

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First Name

I.

Last Name

Abdel-Sabour

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Volume

17

Article Issue

2

Related Issue

10609

Issue Date

1994-12-01

Receive Date

1994-07-31

Publish Date

1994-12-31

Page Start

139

Page End

146

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 2_Pages 139-146.pdf

PDF . 489.5kB

Link

https://bpsa.journals.ekb.eg/article_69800.html

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https://bpsa.journals.ekb.eg/service?article_code=69800

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECTS OF POROUS SILICA AS DRUG CARRIER ON THE FORMULATION OF EFFERVESCENT NYSTATIN VAGINAL TABLETS

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Article

Created At

22 Jan 2023