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69798

FORMULATION OF OILY DRUGS IN POWDER FORM USING POROUS SILICAS I. VITAMIN E

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Last updated: 04 Jan 2025

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Abstract

Porous calcium silicate (florite R) and controlled pore glass (CPG 75 & CPG 500) were investigated as carriers to formulate vitamin E in a free flowing powder form. The prepared dispersions were subjected to thermogravemetric analysis (TG), scanning electron microscopic examination, testing of flow ability, uniformity of content and in-vitro release of vitamin E. TG of vitamin E - porous silicas. dispersions indicated that vitamin E existed in both lightly and strongly bound state. The latter was directly related to the specific surface area of the carrier. Florite R was found to have a greater ability to hold vitamin E than controlled pore glass. the dispersions prepared using florite R and containing up to 40% w/w vitamin E showed good flowability, uniformity of content and almost 100% release of the loaded drug.

DOI

10.21608/bfsa.1994.69798

Authors

First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Yoshinbu

Last Name

Nakai

MiddleName

-

Affiliation

Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoicho, Chiba 263, Japan

Email

-

City

-

Orcid

-

First Name

A.

Last Name

El-Sayed

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Ali

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

17

Article Issue

2

Related Issue

10609

Issue Date

1994-12-01

Receive Date

1994-07-09

Publish Date

1994-12-31

Page Start

119

Page End

125

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 2_Pages 119-125.pdf

PDF . 431.2kB

Link

https://bpsa.journals.ekb.eg/article_69798.html

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https://bpsa.journals.ekb.eg/service?article_code=69798

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION OF OILY DRUGS IN POWDER FORM USING POROUS SILICAS I. VITAMIN E

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Article

Created At

22 Jan 2023