ManageChatDiscover
69795

NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The possible involvement of the synclinal conformation of mescaline with phencyclidine (PCP)-receptors has promoted the synthesis of certain novel structural hybrids of mescaline with PCP-analogs. The effect of mescaline and the potential antagonisticactivity of the newly proposed derivatives at central PCP-receptors of albino rat brains will await investigation. The suggested compounds were chemically 1-aryl-1-(3,4,5-trimethoxy; or trihydroxy) phenethylamino; or N-substituted-phenethylamino cycloalkanes. An N-(2-chloroethyl) moiety was, also incorporated into some of the designed analogs for exploration of the possible participation of such alkylating arm to the elicited activity.

DOI

10.21608/bfsa.1994.69795

Authors

First Name

M.

Last Name

Abdel-Kreem

MiddleName

F. M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

El-Semary

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Email

-

City

-

Orcid

-

First Name

N.

Last Name

Eshba

MiddleName

H.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Email

-

City

-

Orcid

-

First Name

R.

Last Name

Shafik

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Email

-

City

-

Orcid

-

Volume

17

Article Issue

2

Related Issue

10609

Issue Date

1994-12-01

Receive Date

1994-07-03

Publish Date

1994-12-31

Page Start

105

Page End

112

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 2_Pages 105-112.pdf

PDF . 431.9kB

Link

https://bpsa.journals.ekb.eg/article_69795.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=69795

Order

2

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS

Details

Type

Article

Created At

22 Jan 2023