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69792

STUDY OF CHARGE-TRANSFER COMPLEXES BETWEEN IODINE AND SOME ANTIDEPRESSANTS

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Last updated: 25 Dec 2024

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Abstract

Molecular interactions between iodine and various antidepressants are investigated by UV/Vis spectroscopy. Iodine is found to form charge-transfer complexes (CTC) of n-type with these molecules. Beer's law is obeyed in the concentration range 0.5-30 mg/ml for the studied compounds. The values for the formation constants Kc of these iodinated complexes indicate a strong donor-acceptor interaction. These drugs can, therefore, be expected to interfere with thyroid metabolism. In addition, a good correlation between log € and some antidepressant parameters is found.

DOI

10.21608/bfsa.1994.69792

Authors

First Name

Ibrahim

Last Name

Refaat

MiddleName

H.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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Orcid

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First Name

Osama

Last Name

Abdelmageed

MiddleName

H.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Hassan

Last Name

Askal

MiddleName

F.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Gamal

Last Name

Saleh

MiddleName

A.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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Orcid

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Volume

17

Article Issue

1

Related Issue

10608

Issue Date

1994-07-01

Receive Date

1994-04-05

Publish Date

1994-07-31

Page Start

87

Page End

94

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 1_Pages 87-94.pdf

PDF . 430.1kB

Link

https://bpsa.journals.ekb.eg/article_69792.html

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https://bpsa.journals.ekb.eg/service?article_code=69792

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

STUDY OF CHARGE-TRANSFER COMPLEXES BETWEEN IODINE AND SOME ANTIDEPRESSANTS

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Article

Created At

22 Jan 2023