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69791

EFFECT OF BLOCK COPOLYMERS ON THE DISSOLUTION OF SOME WATER-INSOLUBLE DRUGS: 1. NIFEDIPINE-PLURONIC F-127 SOLID DISPERSION SYSTEM

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Last updated: 04 Jan 2025

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Abstract

The effect of pluronic F-127, a block copolymer, on enhancing the dissolution rate of water-insoluble drugs was studied. Solid dispersions of nifedipine, a model water-insoluble drug, with pluronic F-127 and PVP at different drug : polymer ratios were prepared using the solvent-evaporation method. The dissolution profiles of solid dispersion samples in distilled water at 37°C were compared to those using physical mixtures of the same composition. The results showed that solid dispersion technique using both PVP and pluronic F-127 dramatically increased the dissolution rate of nifedipine. X-ray and differential scanning calorometric (DSC) studies were performed on different samples in order to elucidate mechanism(s) of the dissolution enhancement effect exerted by both polymers. It was concluded that the increase in dissolution rate of nifedipine from the solid dispersion is due to the lack of the drug crystallinity in these formulations. This improvement in the drug release rate can lead to an improvement in its bioavailability.

DOI

10.21608/bfsa.1994.69791

Authors

First Name

Sayed

Last Name

Khidr

MiddleName

H.

Affiliation

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

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Volume

17

Article Issue

1

Related Issue

10608

Issue Date

1994-07-01

Receive Date

1994-02-28

Publish Date

1994-07-31

Page Start

81

Page End

86

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 1_Pages 81-86.pdf

PDF . 307.5kB

Link

https://bpsa.journals.ekb.eg/article_69791.html

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https://bpsa.journals.ekb.eg/service?article_code=69791

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9

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF BLOCK COPOLYMERS ON THE DISSOLUTION OF SOME WATER-INSOLUBLE DRUGS: 1. NIFEDIPINE-PLURONIC F-127 SOLID DISPERSION SYSTEM

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Article

Created At

22 Jan 2023