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69790

PHARMACEUTICAL AND HISTOLOGICAL STUDIES OF NEW SOLUBLE DIAZEPAM

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Last updated: 25 Dec 2024

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Abstract

Lyophilization technique has been adopted to enhance the aqueous solubility of diazepam. Two hydrophilic polymers namely; polyvinyl pyrrolidone 44000 (PVP) and pluronic F-127 (PF-127) in different ratios were used as the adjuvents in preparing the freeze-dried samples. Of the tested ratios, diazepam: PVP (1:10) and diazepam: PF-127 (1:60) were found to gave the highest solubility of the drug. The dissolution studies revealed that lyophilized diazepam samples required from 1-3 minutes to dissolve compared to 20 minutes in case of untreated drug. Histological evaluations were performed after S.C. and I.M. injection into mice. A slight histological changes were induced. Consequently, the prepared lyophilized-diazepam product can be reconstituted with ease using phosphate buffer (pH 7.2) for parenteral administration, as well as it can met the requirement of zydis.

DOI

10.21608/bfsa.1994.69790

Authors

First Name

S.

Last Name

El-Harras

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Shawky

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Hafez

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Shaker

MiddleName

-

Affiliation

Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

17

Article Issue

1

Related Issue

10608

Issue Date

1994-07-01

Receive Date

1994-02-28

Publish Date

1994-07-31

Page Start

73

Page End

79

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 1_Pages 73-79.pdf

PDF . 498.0kB

Link

https://bpsa.journals.ekb.eg/article_69790.html

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https://bpsa.journals.ekb.eg/service?article_code=69790

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PHARMACEUTICAL AND HISTOLOGICAL STUDIES OF NEW SOLUBLE DIAZEPAM

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Article

Created At

22 Jan 2023