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SELECTIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF D-PENICILLAMINE BULK DRUG AND CAPSULES IN THE PRESENCE OF SOME PENICILLINS AND THEIR DEGRADATION PRODUCTS

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Last updated: 25 Dec 2024

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Abstract

Three simple, rapid and sensitive spectrophotometric methods for the assay of D-penicillamine in the presence of some penicillin preparations as well as common penicillin degradation products were carried out. These methods are based on the oxidation of penicillamine with ferric  ion in aqueous solution. The indirect quantitation of the produced ferrous ions was carried out at 523, 690 and 510 nm for ferro-bipyridyl, ferro-ferricyanide and ferro-1,10-phenanthroline complexes respectively. All variables were studied to optimize the reaction conditions. Regression analysis of Beer's plot showed good correlation in a general concentration range of 1-10 mg D-penicillamine/ml. No interference could be observed from the presence of many structurally relevant compounds. In addition, common pharmaceutical adjuvants present incapsules did not interfere. The validity of the proposed methods was tested by analyzing artaminecapsules. Recoveries were 99.5 - 100.9%.

DOI

10.21608/bfsa.1994.69789

Authors

First Name

Gamal

Last Name

Saleh

MiddleName

A.

Affiliation

Department of Pharmaceutica1Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Hassan

Last Name

Askal

MiddleName

F.

Affiliation

Department of Pharmaceutica1Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Osama

Last Name

Abdelmageed

MiddleName

H.

Affiliation

Department of Pharmaceutica1Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

Ibrahim

Last Name

Refaat

MiddleName

H.

Affiliation

Department of Pharmaceutica1Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

17

Article Issue

1

Related Issue

10608

Issue Date

1994-07-01

Receive Date

1994-02-22

Publish Date

1994-07-31

Page Start

65

Page End

71

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 1_Pages 65-71.pdf

PDF . 394.3kB

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https://bpsa.journals.ekb.eg/article_69789.html

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https://bpsa.journals.ekb.eg/service?article_code=69789

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SELECTIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF D-PENICILLAMINE BULK DRUG AND CAPSULES IN THE PRESENCE OF SOME PENICILLINS AND THEIR DEGRADATION PRODUCTS

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Article

Created At

22 Jan 2023