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69787

INFLUENCE OF -CYCLODEXTRIN ON THE NYSTATIN RELEASE FROM OINTMENTS AND ITS ANTIFUNGAL EFFECT

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Last updated: 25 Dec 2024

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Abstract

Thesolid complex of nystatin-g-cyclodextrin (g-CD) in a molar ratio 1:1 was prepared. Physico-chemical characteristics of the nystatin-g-CD) complex was studied by x-ray diffraction, differential scanning calorimetry and infrared spectroscopy. Absorption and hydrophilic (o/w) ointments were prepared, containing each of the intact drug, the g-CD complex and .the physical mixture of the drug with g-CD; respectively. The in-vitro release of nystatin from both types of ointments was examined and the concentration of nystatin released was estimated by HPLC method using Cyclobond column-for the resolution of the drug. The release kinetic mechanism was found to follow both diffusion controlled and first-order kinetic mechanisms. The solid complex-prepared showed improved release from o/w rather than absorption ointment bases as well as enhanced antifungal effect against Candida Albicans.

DOI

10.21608/bfsa.1994.69787

Authors

First Name

Salwa

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Samia

Last Name

El-Gizawy

MiddleName

M.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

Ehsan

Last Name

Elsabour

MiddleName

A.

Affiliation

Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Volume

17

Article Issue

1

Related Issue

10608

Issue Date

1994-07-01

Receive Date

1993-12-06

Publish Date

1994-07-31

Page Start

49

Page End

56

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 1_Pages 49-56.pdf

PDF . 453.3kB

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https://bpsa.journals.ekb.eg/article_69787.html

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https://bpsa.journals.ekb.eg/service?article_code=69787

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

MainTitle

INFLUENCE OF -CYCLODEXTRIN ON THE NYSTATIN RELEASE FROM OINTMENTS AND ITS ANTIFUNGAL EFFECT

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Article

Created At

22 Jan 2023