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69784

SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW 1,3,4-OXADIAZOLES AND 2-SUBSTITUTED AMINO-L,3,4-OXADIAZOLE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY

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Last updated: 25 Dec 2024

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Abstract

New 2-[4-(3-acetyl-2-substituted- 2,3-dihydro-1,3,4-oxadiazol-5-yl)phenoxymethyl]-1H-bezimidazoles (V) and 2-[4-(3-acetyl-2-substituted-2,3-diydro-1,3,4-oxadiazol-5yl)phenoxymetyl]-1-methyl-1H-benzimidazoles (VI) were synthesized by cyclization of 2-[4-alkylidene or arylidenehydrazinocarbonyl)phenoxymethyl]-1H-benzimidazoles (III) or 2-[4-(alkylidene or arylidenehydrazinocarbonyl)phenoxymethyl]-1-methyl-1H-benzimidazoles (IV) with acetic anhydride.
New series of 2-[4-substitutedamino-1,3,4-oxadiazol-5-yl)phenoxymethyl]-1H-benzimidazoles (IX) and 2-[4-substitutedamino-1,3 ,4-oxadiazol-5-yl)phenoxymethyl]-1-methyl-1H-benzimidazoles (X) were obtained by cyclodesulfurization of 2-[4-(substitutedthiocarbamoylhydrazinocarbonyl)phenoxymethyl]-1H-benzimidazoles (VII) or 2-[4-(substitutedthiocarbamoylhydrazi nocarbonyl)phenoxymethyl]-1-methyl-1H-benzimidazoles (VIII). The structure of the newly synthesized compounds were elucidated by elemental analysis, IR and 1H-NMR spectra. Their antimicrobial activity was studied.

DOI

10.21608/bfsa.1994.69784

Authors

First Name

F.

Last Name

Ashour

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

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First Name

S.

Last Name

El-Hawash

MiddleName

A. M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

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Orcid

-

First Name

M.

Last Name

Mahran

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

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Orcid

-

First Name

A.

Last Name

Yousry

MiddleName

H.

Affiliation

Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt

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City

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Orcid

-

First Name

A.

Last Name

Harnouda

MiddleName

F.

Affiliation

Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt

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Volume

17

Article Issue

1

Related Issue

10608

Issue Date

1994-07-01

Receive Date

1993-09-09

Publish Date

1994-07-31

Page Start

17

Page End

25

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 17_Issue 1_Pages 17-25.pdf

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https://bpsa.journals.ekb.eg/article_69784.html

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https://bpsa.journals.ekb.eg/service?article_code=69784

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1,096

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Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW 1,3,4-OXADIAZOLES AND 2-SUBSTITUTED AMINO-L,3,4-OXADIAZOLE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY

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Article

Created At

22 Jan 2023