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69706

HAEMATOXYLIN-PERMANGANATE REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF SOME THIOL DRUGS

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Last updated: 25 Dec 2024

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Abstract

A new rapid and sensitive spectrophotometric method was developed for the determination of six thiol pharmaceutical compounds. The method is based on the spontaneous oxidation of the thiol group with a constant small concentration of potassium permanganate followed by the rapid reaction of the excess permanganate with haematoxylin reagent in neutral aqueous medium. Haematoxylin is oxidized to the coloured chromogen, haematein which was measured at 558 nm. A linear relationship was obtained between drug concentration and the decrease in absorbance readings. The method was applied for the determination of the investigated compounds either in authentic powders or in some .dosage forms. Good agreement was obtained with the reported methods. In addition, the suggested method was tried as stability indicating assay for the investigated thiol drugs.

DOI

10.21608/bfsa.1995.69706

Authors

First Name

Ibrahim

Last Name

Refaat

MiddleName

H.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

18

Article Issue

2

Related Issue

10588

Issue Date

1995-12-01

Receive Date

1995-08-03

Publish Date

1995-12-31

Page Start

135

Page End

141

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 18_Issue 2_Pages 135-141.pdf

PDF . 444.5kB

Link

https://bpsa.journals.ekb.eg/article_69706.html

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https://bpsa.journals.ekb.eg/service?article_code=69706

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

HAEMATOXYLIN-PERMANGANATE REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF SOME THIOL DRUGS

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Article

Created At

22 Jan 2023