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69704

PREPARATION AND EVALUATION OF PHENYLTOLOXAMINE CITRATE MICROSPHERES

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Last updated: 25 Dec 2024

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Abstract

Microspheres of phenyltoloxamine citrate (PTC) with cellulose acetate butyrate (CAB) were prepared using an emulsion-solvent evaporation technique. Good reproducibility in microspheres preparation was observed. The recovery of drug from different microspheres varied between 87 and 94 %. The release rates of the drug from these microsphres were decreased as compared with that from the drug powder. Different release characteristics were obtained by changing the drug-to-polymer ratio and varying the particle size of micro spheres. As the polymer to drug ratio increased, the microsphere size distribution shifted to the smaller size and the release of the drug decreased. The release of the drug showed pH-dependence. The release kinetics of the drug from CAB microspheres were studied. The antihistamine and the analgesic activities of PTC alone and PTC microspheres were evaluated in vivo. The antihistamine and analgesic activities of the tested microspheres in vivo were found to be greater and more prolonged than that of the intact drug.

DOI

10.21608/bfsa.1995.69704

Authors

First Name

E.

Last Name

Samy

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

F.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Ali

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Anwar

MiddleName

M.

Affiliation

Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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Volume

18

Article Issue

2

Related Issue

10588

Issue Date

1995-12-01

Receive Date

1995-08-26

Publish Date

1995-12-31

Page Start

125

Page End

134

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 18_Issue 2_Pages 125-134.pdf

PDF . 667.8kB

Link

https://bpsa.journals.ekb.eg/article_69704.html

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https://bpsa.journals.ekb.eg/service?article_code=69704

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF PHENYLTOLOXAMINE CITRATE MICROSPHERES

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Article

Created At

22 Jan 2023