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69679

KINETIC STUDIES ON THE ALKYLATING ACTIVITY OF CERTAIN NEW CHALCONES OF ACETYLPYRIDINES

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Last updated: 25 Dec 2024

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Abstract

The synthesis of a number of chalcones derived from acetylpyridines and some p-substituted benzaldehydes has been accomplished. These compounds were evaluated for their alkylating activity by kinetic studies of their reaction with 2-mercaptoethanol. Compounds with electron withdrawing groups in the p-position of benzylidine moiety showed higher activities than compounds with electron donating groups. Quaternization of the pyridine ring decreased activity profoundly.

DOI

10.21608/bfsa.1995.69679

Authors

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Last Name

El-Koussi

MiddleName

A.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

18

Article Issue

1

Related Issue

10585

Issue Date

1995-06-01

Receive Date

1994-11-14

Publish Date

1995-06-30

Page Start

49

Page End

53

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 18_Issue 1_Pages 49-53.pdf

PDF . 250.1kB

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https://bpsa.journals.ekb.eg/article_69679.html

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https://bpsa.journals.ekb.eg/service?article_code=69679

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

KINETIC STUDIES ON THE ALKYLATING ACTIVITY OF CERTAIN NEW CHALCONES OF ACETYLPYRIDINES

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Article

Created At

22 Jan 2023