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69665

OCULAR BIOAVAILABILITY OF PREDNISOLONE FROM MULTIPLE EMULSION DELIVERY SYSTEMS

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Last updated: 25 Dec 2024

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Abstract

Studies were conducted to evaluate the performance of prednisolone in multiple emulsions as drug delivery systems on the inflamed rabbit's eye. Multiple emulsions w/o/w and o/w/o were prepared by re-emulsification technique. Evaluation of the emulsions was done immediately after the preparation by microscopical examination. Topical instillation of simple emulsion treatments were also investigated for the purpose of comparison. Follow up of the outcome of control and test treatments was made daily by instillation of fluorescein solution and counting the number of induced ulcers. The comparison of the healing rate in control and test treatments groups showed marked differences between the groups. These differences are not only pronounced with regard to the rate of healing but also to its extent. Statistical analysis of differences between the control group and the different test groups with regard to the number of residual ulcers throughout the observation period of four weeks was made according to the student t-test.

DOI

10.21608/bfsa.1995.69665

Authors

First Name

M.

Last Name

Kassem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Attia

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

El-Mahdy

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

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Volume

18

Article Issue

1

Related Issue

10585

Issue Date

1995-06-01

Receive Date

1994-11-13

Publish Date

1995-06-30

Page Start

15

Page End

21

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_69665.html

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https://bpsa.journals.ekb.eg/service?article_code=69665

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

OCULAR BIOAVAILABILITY OF PREDNISOLONE FROM MULTIPLE EMULSION DELIVERY SYSTEMS

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Article

Created At

22 Jan 2023