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68783

ANALYTICAL STUDY OF SOME ANTIHISTAMINES WITH HAEMATOXYLIN REAGENT

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Last updated: 25 Dec 2024

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Abstract

The reaction between haematoxylin reagent and eight antihistaminic drugs (chlorpheniramine maleate, pheniramine maleate, cyproheptadine hydrochloride; astemizole, terfenadine, ranitidine hydrochloride, famotidine and cimitidine) was investigated and utilized as the basis for a new, simple and sensitive spectrophotometric procedure for their determinations. The procedure is based on the reaction of the methanolic solution of the anti-histaminic compounds with haematoxylin reagent in 3x10-3 M boric acid to give a reddish-violet colour (lmax 555 nm). The absorbance was linear with all compounds over the 5-200 µg/ml general concentration range of the final measured antihistamine base solution. A good correlation was found between log A (1%, 1 cm) and pka values for six of the studied drugs. The method can be applied successfully to the analysis of commercially available tablet formulations. No interference was observed due to additives which are commonly present in tablet formulations or coformulated compounds such as phenazone, phenazone salicylate, sodium salicylate paracetamol, propyphenazone and caffeine.

DOI

10.21608/bfsa.1996.68783

Authors

First Name

Osama

Last Name

Abdelmageed

MiddleName

H.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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Volume

19

Article Issue

1

Related Issue

10412

Issue Date

1996-10-01

Receive Date

1996-09-15

Publish Date

1996-10-31

Page Start

53

Page End

62

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 19_Issue 1_Pages 53-62.pdf

PDF . 617.4kB

Link

https://bpsa.journals.ekb.eg/article_68783.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=68783

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6

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANALYTICAL STUDY OF SOME ANTIHISTAMINES WITH HAEMATOXYLIN REAGENT

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Article

Created At

22 Jan 2023