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68782

INCLUSION COMPLEXATION OF BENZTHIAZIDE WITH CYCLODEXTRINS IN SOLUTION AND SOLID PHASE

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Last updated: 25 Dec 2024

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Abstract

Investigations were made to prepare the inclusion compounds of Benzthiazide (BTZ) with b-cyclodextrin (b-CD), g-cyclodextrin (g-CD) and dimethyl-b-cyclodextrin (DMCD) in solid powdered form by the freeze-drying and the grinding methods. The freeze drying and grinding methods were successful in obtaining the inclusion compounds of BTZ with the cyclodextrins (CDs). All the inclusion compounds obtained via freeze drying and grinding methods were in powdered form. It was shown by X-ray diffractometery that the inclusion compounds obtained by the two methods were amorphous. Clear differences in infrared (IR) absorption spectroscopy and differential scanning calorimetry were observed between the inclusion compounds and the physical mixtures of BTZ-CDs. Furthermore, inclusion complexation of BTZ with g-CD, DMCD and b-CD in aqueous solutions were confirmed by the solubility method. The solubility curves of BTZ-g-CD and BTZ-DMCD were typical AL type curves while the solubility curve with b-CD can be classified as type Ap. The apparent stability constants, Kc, were calculated from the slope and intercept of the solubility diagrams 1110 M-1, 3053 M-1 and 1268 M-1 respectively. The dissolution rate of BTZ from the inclusion complexes was much more rapid than that of the BTZ alone. The enhanced dissolution rate may be due to the decrease in crystallinity and the increase in apparent solubility of the drug of the freeze-dried and ground samples, as expected from X-ray diffractometery and solubility study.

DOI

10.21608/bfsa.1996.68782

Authors

First Name

Gamal

Last Name

El-Gendy

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

Ahmed

Last Name

Aly

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

A.

Last Name

El-Sayed

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

19

Article Issue

1

Related Issue

10412

Issue Date

1996-10-01

Receive Date

1995-02-26

Publish Date

1996-10-31

Page Start

45

Page End

52

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 19_Issue 1_Pages 45-52.pdf

PDF . 417.5kB

Link

https://bpsa.journals.ekb.eg/article_68782.html

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https://bpsa.journals.ekb.eg/service?article_code=68782

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INCLUSION COMPLEXATION OF BENZTHIAZIDE WITH CYCLODEXTRINS IN SOLUTION AND SOLID PHASE

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Article

Created At

22 Jan 2023