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68775

FORMULATION AND EVALUATION OF CONTROLLED RELEASE IBUPROFEN TABLETS

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Last updated: 25 Dec 2024

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Abstract

Controlled release ibuprofen tablets were prepared by coevaporation technique using Eudragit RSPM, ethylcellulose 20, Aerosil R972 and Aerosil 200 as carriers and Avicel pH102 as filler. The effect of different compression forces on the release rate of the drug was studied. The carriers used produce retardation in the release rate of ibuprofen in the following manner: Eudragit RSPM > ethylcellulose 20 > Aerosil R972 > Aerosil 200. The dependence of release rate (K) on hardness (H) may be approximated by the equation, Ln K = a H + b. The release mechanism follows zero order kinetic. The antiinflammatory activity of the coevaporates was studied in albino rats using trypan-blue method. The coevaporates were also tested in albino mice for their analgesic activity using hot plate and p-benzoquinone induced writhing methods. The obtained results revealed that Eudragit RSPM and Aerosil 200 were the most effective in sustaining the antiinflammatory and analgesic actions of ibuprofen, while ethylcellulose 20 was the least effective. Histological examination of rat's stomach proved the efficiency of the tested coevaporates in inhibiting the ulcerogenic effects caused by the plain drug.

DOI

10.21608/bfsa.1996.68775

Authors

First Name

Eman

Last Name

Samy

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assuit University, Assiut, Egypt

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City

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Orcid

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First Name

Ahmed

Last Name

Abdel Zaher

MiddleName

O.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assuit University, Assiut, Egypt

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City

-

Orcid

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First Name

Safaa

Last Name

Abdel Maksoud

MiddleName

A.

Affiliation

Department of Histology, Faculty of Medicine, Assuit University, Assiut, Egypt

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-

City

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Orcid

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Volume

19

Article Issue

1

Related Issue

10412

Issue Date

1996-10-01

Receive Date

1995-06-19

Publish Date

1996-10-31

Page Start

1

Page End

14

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 19_Issue 1_Pages 1-14.pdf

PDF . 413.4kB

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https://bpsa.journals.ekb.eg/article_68775.html

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https://bpsa.journals.ekb.eg/service?article_code=68775

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF CONTROLLED RELEASE IBUPROFEN TABLETS

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Article

Created At

22 Jan 2023