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68755

SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY

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Last updated: 04 Jan 2025

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Abstract

A series of 1-methyl-3-[N-(substituted benzalimino)carbamoyl] pyridinium iodide and their corresponding dihydropyridines were prepared by conventional methods. The prepared compounds were tested in vitro for their MAO inhibitory activity on liver mitochondria by kynuramine fluorimetric assay. The results showed that MAOI activity of quaternaries is more than the corresponding dihydro compounds. 

DOI

10.21608/bfsa.1997.68755

Authors

First Name

Nawal

Last Name

El-Koussi

MiddleName

A.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

Hoda

Last Name

Hassan

MiddleName

Y.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Hassan

Last Name

Farag

MiddleName

H.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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Volume

20

Article Issue

2

Related Issue

10408

Issue Date

1997-12-01

Receive Date

1997-06-02

Publish Date

1997-12-31

Page Start

155

Page End

161

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 20_Issue 2_Pages 155-161.pdf

PDF . 384.1kB

Link

https://bpsa.journals.ekb.eg/article_68755.html

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https://bpsa.journals.ekb.eg/service?article_code=68755

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6

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY

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Article

Created At

22 Jan 2023