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68751

FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS

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Last updated: 25 Dec 2024

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Abstract

Three matrix excipients namely: Hydroxypropylmethylcellulose (HPMC), sodium carboxymethyl cellulose (NaCMC) and egg albumin (EA) were utilized for the preparation of controlled release matrix tablets containing 200 mg of aminophylline. The prepared tablets were evaluated with respect to physical parameters and dissolution rate. All formulations showed acceptable physical parameters. The release rate was variable depending on the composition of the matrix tablet. There was no significant difference between the dissolution rates of the matrix tablets prepared with HPMC or EA. The lowest release rate was observed in case of the matrix tablets prepared using NaCMC either alone or in combination with either HPMC or EA. The dissolution data of the drug from most matrix tablets formulation were fitted to Higuchi diffusion model.

DOI

10.21608/bfsa.1997.68751

Authors

First Name

Ahmed

Last Name

Ali

MiddleName

Shaker

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

Adel

Last Name

Ali

MiddleName

Mohamed

Affiliation

Faculty of Pharmacy, Al-Isra University, Amman, Jordan

Email

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City

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Orcid

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First Name

Fergany

Last Name

Mohammed

MiddleName

Abd El-Hameed

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

20

Article Issue

2

Related Issue

10408

Issue Date

1997-12-01

Receive Date

1996-11-10

Publish Date

1997-12-31

Page Start

141

Page End

146

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 20_Issue 2_Pages 141-146.pdf

PDF . 388.3kB

Link

https://bpsa.journals.ekb.eg/article_68751.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=68751

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS

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Article

Created At

22 Jan 2023