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IN VITRO RELEASE OF FREEZE-DRIED MEFENAMIC ACID-POLOXAMER FROM SUPPOSITORY BASES AND EVALUATION OF ITS ANTI-INFLAMMATORY EFFECT

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Last updated: 04 Jan 2025

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Abstract

The in vitro release of mefenamic acid (MFA) as well as its freeze-dried forms with poloxamer 409 (PF-127) in different ratios [(9:1), (1:1)] from suppository bases was investigated and confirmed with DSC and X-ray. The release rate of MFA from lipophilic base (WH15) and hydrophilic base (3PEG 1000:7 PEG 4000) in NaOH, KH2PO4 buffer at 37°C was performed. The release pattern of MFA:PF-127 freeze-dried samples from both selected bases was remarkably higher than that of pure untreated drug. However, the release of the drug as indicated by permeability rate constant was much more faster from WH15 compared to PEG using the same ratio of drug:PF-127 (8.037 vs 1.827, respectively). MFA:PF-127 (1:1) freeze-dried formulated in WH15 and PEG suppository bases were evaluated by the carrageenin induced rabbit hindpaw edema. Both formulas resulted in inhibition of edema formation l hr post medication (58.6%, and 41.4%, respectively) which was significantly greater than the rectal MFA as received in WH15 (14.7%).

DOI

10.21608/bfsa.1997.68745

Authors

First Name

S.

Last Name

El-Harras

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

20

Article Issue

1

Related Issue

10407

Issue Date

1997-06-01

Receive Date

1997-06-05

Publish Date

1997-06-30

Page Start

95

Page End

104

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 20_Issue 1_Pages 95-104.pdf

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https://bpsa.journals.ekb.eg/article_68745.html

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https://bpsa.journals.ekb.eg/service?article_code=68745

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN VITRO RELEASE OF FREEZE-DRIED MEFENAMIC ACID-POLOXAMER FROM SUPPOSITORY BASES AND EVALUATION OF ITS ANTI-INFLAMMATORY EFFECT

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Article

Created At

22 Jan 2023