Beta
ManageSearchChatDiscover
68743

REDOX SPECTROPHOTOMETRIC DETERMINATION OF FLUOROQUINOLONE ANTIBIOTICS DOSAGE FORMS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

A general difference spectrophotometric procedure for the determination of seven antibacterial 7-piperazine fluoroquinolone derivatives in the range of 2-20 µg/ml is proposed. The procedure is based on the oxidation of these antibiotics using 1 ml of 0.5 mg/ml potassium permanganate in presence of 20% sulphuric acid at room temperature (25±5°C) for 10 min. The decrease in permanganate color (DA) due to the interaction with such organic compounds is measured at 520 nm. Molar ratio determination indicated 1:3 (drug: permanganate). Assay precision (RSD) values were ±1.5% or better for the bulk drugs and ranged from ±1.38 to ± 1.2% for tablets and ampoules. Drug recoveries were quantitative from the dosage forms tested. The proposed procedure is simple, rapid, accurate and readily applied to the determination of this new class of antibiotics in pharmaceutical products without interference from other ingredients or common additives.

DOI

10.21608/bfsa.1997.68743

Authors

First Name

Hassan

Last Name

Askal

MiddleName

F.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

20

Article Issue

1

Related Issue

10407

Issue Date

1997-06-01

Receive Date

1996-11-14

Publish Date

1997-06-30

Page Start

75

Page End

85

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 20_Issue 1_Pages 75-85.pdf

PDF . 651.9kB

Link

https://bpsa.journals.ekb.eg/article_68743.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=68743

Order

10

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

REDOX SPECTROPHOTOMETRIC DETERMINATION OF FLUOROQUINOLONE ANTIBIOTICS DOSAGE FORMS

Details

Type

Article

Created At

22 Jan 2023