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68738

SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES

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Last updated: 25 Dec 2024

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Abstract

A series of 3(5)-substituted 1,2,4-triazole-5(3)-carboxylic acid amides, hydroxamic, hydrazide, iminosemicarbazide, semicarbazide and thiosemicarbazide have been synthesized. Most of the prepared compounds were tested for their growth inhibitory activity against Staph. aureus and E. coli and none of them revealed antibacterial activity at concentration up to 2.5 mg/mL. The 5(3)-iminosemicarbazides (8h, 9h, 10h, 11h), 5(3)-semicarbazides (8i, 9i, 10i, 11i) and 5(3)-thiosemicarbazides (8j, 9j, 10j) were chosen for evaluation of their potentialities to lower blood glucose level in rats. The oral glucose tolerance test was used as preliminary test for evaluation of hypoglycemic activity of these compounds. The tested compounds showed different onset and duration of action.

DOI

10.21608/bfsa.1997.68738

Authors

First Name

A.

Last Name

Abd-Elhafez

MiddleName

A.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiui, Egypt

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First Name

H.

Last Name

Mohamed

MiddleName

M.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiui, Egypt

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-

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-

Orcid

-

First Name

H.

Last Name

Hassan

MiddleName

Y.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiui, Egypt

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-

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-

Orcid

-

First Name

G.

Last Name

El-Karamany

MiddleName

S.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiui, Egypt

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-

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-

Orcid

-

First Name

N.

Last Name

El-Koussi

MiddleName

A.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiui, Egypt

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-

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Orcid

-

First Name

A.

Last Name

Youssef

MiddleName

F.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiui, Egypt

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Volume

20

Article Issue

1

Related Issue

10407

Issue Date

1997-06-01

Receive Date

1996-11-13

Publish Date

1997-06-30

Page Start

47

Page End

61

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 20_Issue 1_Pages 47-61.pdf

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https://bpsa.journals.ekb.eg/article_68738.html

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https://bpsa.journals.ekb.eg/service?article_code=68738

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES

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Article

Created At

22 Jan 2023