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68734

UTILITY OF 5-DIAZO-1,2,4-TRIAZOL-3-CARBOXYLIC ACID FOR COLORIMETRIC DETERMINATION OF SOME DIBENZAZEPINES

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Last updated: 04 Jan 2025

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Abstract

A simple, rapid, and accurate spectrophotometric method for determination of four dibenzazepines has been developed. The method is based on the interaction of 5-diazo-1,2,4-triazole-3-carbaxylic acid (DTCA) with dibenzazepine drugs in 10% nitric acid media. The resulting colored products possess 2 absorption maxima, one in the range of 475-495 nm with higher molar absorptivity and the other in the range of 570-575 nm with lower molar absorptivity. Measurements were performed in the range of 475-495 nm. Beer's law is obeyed in the concentration range of 2-10 µg/ml for both imipramine HCl and desipramine HCl and 2-14 µg/ml for both clomipramine HCl and trimipramine maleate. The molar absorptivities of the studied drugs are 2.877x 104 for imipramine HCl at 487 nm., 3.164 x 104 for desipramine HCl at 495 nm., 2.002 x l04 for clomipramine HCl at 475 nm. and 2.350 x 104 for trimipramine maleate at 475 nm. The proposed method is applied successfully for the determination of studied drugs in pure form and in commercial and laboratory prepared tablets. The obtained results are in good agreement with those obtained from official methods.

DOI

10.21608/bfsa.1997.68734

Authors

First Name

Nawal

Last Name

El-Koussi

MiddleName

A.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Horria

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

Abd El-Maaboud

Last Name

Mohamed

MiddleName

I.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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Volume

20

Article Issue

1

Related Issue

10407

Issue Date

1997-06-01

Receive Date

1996-10-05

Publish Date

1997-06-30

Page Start

17

Page End

22

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 20_Issue 1_Pages 17-22.pdf

PDF . 334.9kB

Link

https://bpsa.journals.ekb.eg/article_68734.html

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https://bpsa.journals.ekb.eg/service?article_code=68734

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

UTILITY OF 5-DIAZO-1,2,4-TRIAZOL-3-CARBOXYLIC ACID FOR COLORIMETRIC DETERMINATION OF SOME DIBENZAZEPINES

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Article

Created At

22 Jan 2023