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68733

FORMULATION AND EVALUATION OF COLON-TARGETED TEGAFUR MICROSPHERES

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Last updated: 25 Dec 2024

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Abstract

Tegafur (TGF) is an antineoplastic drug which used for treatment of neoplasm of gastro-intestinal tract including colon cancer. Cellulose acetate butyrate microspheres containing the drug were prepared by using the emulsion-solvent evaporation technique. The microspheres were spherical and free flowing. The yield was greater than 97% and more than 95% of the drug was encapsulated. The effect of microsphere size and pH of the dissolution medium on the drug release was investigated. Sustained release profiles of TGF from TGF-CAB microspheres were observed. In all cases the drug release followed Higuchi diffusion model. Microspheres of smaller size gave a relatively higher dissolution rate of the drug. The drug release was slower in acidic medium (pH 1.2) suggesting that using CAB microspheres would be of value for controlling the drug release and potential colonic-targeting of the drug.

DOI

10.21608/bfsa.1997.68733

Authors

First Name

F.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

G.

Last Name

El-Gendy

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

-

First Name

A.

Last Name

Ali

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

20

Article Issue

1

Related Issue

10407

Issue Date

1997-06-01

Receive Date

1996-09-09

Publish Date

1997-06-30

Page Start

9

Page End

15

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 20_Issue 1_Pages 9-15.pdf

PDF . 417.6kB

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https://bpsa.journals.ekb.eg/article_68733.html

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https://bpsa.journals.ekb.eg/service?article_code=68733

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF COLON-TARGETED TEGAFUR MICROSPHERES

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Article

Created At

22 Jan 2023