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68732

ENHANCEMENT OF DISSOLUTION RATE OF CARBAMAZEPINE: I- IN VITRO STUDIES

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Last updated: 25 Dec 2024

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Abstract

Carbamazepine (CBZ) is an antiepileptic drug which shows variable absorption and variable bioavailability due to poor solubility. Three approaches were utilized to enhance the dissolution rate namely, solvent deposition onto porous silica, co-grinding with porous silica, egg albumin or polyvinylpyrrolidone and surface hydrophilization with non-ionic surfactant or propylene glycol. The molecular behavior of CBZ in the investigated systems were studied using X-ray diffraction analysis and differential scanning calorimetry. The dissolution rate of the drug was also investigated. The obtained results indicated that CBZ was transformed to the amorphous state in both the ground and loaded mixtures with porous silica. This transformation resulted in significant enhancement of the dissolution rates of the drug. Surface hydrophilized rug using 1% w/w polyoxyethylene sorbitan monolaurate (polysorbate 20) showed higher dissolution rate and good compliance with respect to tablet characteristics according to BP 1993 limits.

DOI

10.21608/bfsa.1997.68732

Authors

First Name

Ahmed

Last Name

Ali

MiddleName

Shaker

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

20

Article Issue

1

Related Issue

10407

Issue Date

1997-06-01

Receive Date

1996-08-14

Publish Date

1997-06-30

Page Start

1

Page End

8

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 20_Issue 1_Pages 1-8.pdf

PDF . 453.4kB

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https://bpsa.journals.ekb.eg/article_68732.html

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https://bpsa.journals.ekb.eg/service?article_code=68732

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ENHANCEMENT OF DISSOLUTION RATE OF CARBAMAZEPINE: I- IN VITRO STUDIES

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Article

Created At

22 Jan 2023