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67985

INVESTIGATION OF CONTROLLED RELEASE SOLID DISPERSION OF NAPROXEN USING EUDRAGIT RS AND RL POLYMERS

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Last updated: 25 Dec 2024

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Abstract

Naproxen was used as a model drug and Eudragit RS and RL were used as inert carriers in an attempt to study the controlled release solid dispersion. Naproxen solid dispersion was prepared using solvent evaporation technique. IR study illustrated Naproxen/Eudragits interaction. Dissolution-rate studies showed that the amounts of Naproxen released were found to be fitted to the Higuchi-Square root of time model. The study proved that the solid dispersions composed of Eudragit RS exhibited slow release rates when compared with those composed of Eudragit RL. By a simple modification in the polymeric ratio of both Eudragit RS and Eudragit RL, the kinetics of release can be modulated. A marked reduction in the magnitude of release rates was observed upon increasing the particle size. It was found that there was a linear relationship between the logarithmic value of release rate constant and the fraction of Eudragit RL in the coevaporate composed of Naproxen/RS/RL. The finding was a confirmatory indication that the release was following Higuchi-diffusion model. The study also proved that the compression forces had no effect on the release rate constant. The incorporation of polyvinylpyrrolidone in the coevaporates containing Eudragit RS improved and increased the release profile of Naproxen.

DOI

10.21608/bfsa.1998.67985

Authors

First Name

Mohammed

Last Name

Abd El-Mohsen

MiddleName

G.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

Ahmed

Last Name

Ismail

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Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

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Volume

21

Article Issue

2

Related Issue

10254

Issue Date

1998-12-01

Receive Date

1998-07-29

Publish Date

1998-12-31

Page Start

229

Page End

236

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 21_Issue 2_Pages 229-236.pdf

PDF . 417.8kB

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https://bpsa.journals.ekb.eg/article_67985.html

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https://bpsa.journals.ekb.eg/service?article_code=67985

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INVESTIGATION OF CONTROLLED RELEASE SOLID DISPERSION OF NAPROXEN USING EUDRAGIT RS AND RL POLYMERS

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Article

Created At

22 Jan 2023