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67981

EFFECT OF MICROSPHERONIZATION ON THE RELEASE AND ULCEROGENIC ACTIVITY OF SULINDAC

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Last updated: 25 Dec 2024

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Abstract

Sulindac (SUL) NSAIDS has irritation and ulcerogenic activity on the human stomach. Sulindac microspheres were prepared adopting the solvent evaporation method, using cellulose acetate butyrate as coating polymer with 1-2 drug : polymer ratio. The influence of microsphere particle size and pH of the dissolution medium on the release profile of the drug was investigated. In all cases the drug release mechanism followed Higuchi diffusion model with sustained release profile of sulindac from SUL-CAB microspheres. The smaller particle size gave significantly higher release rate of the drug. The release rate was slower in acidic medium (pH 1.2) than that at pH 7.4. The effect of microspheronization on the ulcerogenic activity of the drug in the stomach of rabbits was studied. It was observed that the ulcerogenic activity of the drug was disappeared and the mucosal surfaces showed free of hemorrhage and inflammations when the drug is used as microspheres.

DOI

10.21608/bfsa.1998.67981

Authors

First Name

A.

Last Name

Abd-Elmageed

MiddleName

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

21

Article Issue

2

Related Issue

10254

Issue Date

1998-12-01

Receive Date

1998-09-15

Publish Date

1998-12-31

Page Start

161

Page End

170

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_67981.html

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https://bpsa.journals.ekb.eg/service?article_code=67981

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7

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF MICROSPHERONIZATION ON THE RELEASE AND ULCEROGENIC ACTIVITY OF SULINDAC

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Article

Created At

22 Jan 2023