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67834

PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS

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Last updated: 04 Jan 2025

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Abstract

Certain new monoamine oxidase inhibitors (MAOIs) containing a pyridinium moiety as an integral part of their structures (Q) were designed. The quaternaries, their corresponding 1,4-dihydroxypyridine derivatives (CDS) and their parent pyridine compounds (P) were synthesized. A spectrofluorimetric method was used to test their in vitro monoamine oxidase inhibition. The compounds showed reasonable activities by the test performed. 

DOI

10.21608/bfsa.1998.67834

Authors

First Name

F.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

N.

Last Name

El-Rabbat

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-

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

P.

Last Name

Khashaba

MiddleName

-

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

-

First Name

H.

Last Name

Farag

MiddleName

H.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

N.

Last Name

Bodor

MiddleName

-

Affiliation

Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, Florida, USA

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Volume

21

Article Issue

1

Related Issue

10245

Issue Date

1998-06-01

Receive Date

1997-12-18

Publish Date

1998-06-30

Page Start

41

Page End

54

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 21_Issue 1_Pages 41-54.pdf

PDF . 692.2kB

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https://bpsa.journals.ekb.eg/article_67834.html

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https://bpsa.journals.ekb.eg/service?article_code=67834

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS

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Article

Created At

22 Jan 2023