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66402

SPECTROPHOTOMETRIC DETERMINATION OF FAMOTIDINE USING P-CBLORANILIC ACID

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Last updated: 25 Dec 2024

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Abstract

Simple and accurate spectrophotometric method/or the analysis of famotidine have been presented. The method was based on the interaction of famotidine and p-chloranillc acid (p­CA) in acetonitrile to give a stable and purple colored product measured at 521 nm. The first derivative value of the interaction product with p-CA was also measured at 323 nm. The optimum experimental parameters have been worked out. Beer's law was obeyed from 25 to 240 µglml and from 2 to 30 µg/ml for the direct absorbance and first derivative measurements respectively. The method enabled the assay of famotidine in its tablets. The derivative method was applied for the determination of famotidine in tablets and spiked urine. Recovery was quantitative and relative standard deviation did not exceed 2 %.
 

DOI

10.21608/bfsa.2000.66402

Authors

First Name

H.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Assiut University, Egypt

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Volume

23

Article Issue

2

Related Issue

9998

Issue Date

2000-12-01

Receive Date

2000-06-19

Publish Date

2000-12-31

Page Start

156

Page End

163

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 23_Issue 2_Pages 156-163.pdf

PDF . 1.7MB

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https://bpsa.journals.ekb.eg/article_66402.html

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https://bpsa.journals.ekb.eg/service?article_code=66402

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC DETERMINATION OF FAMOTIDINE USING P-CBLORANILIC ACID

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Article

Created At

22 Jan 2023