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66367

New chiral amine ligands for enantioselective synthesis of certain (S)- and (R)-monobactams

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Last updated: 04 Jan 2025

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Abstract

Two new tridentate chiral amine ligands I and II mediated the condensation reaction of lithium ester enolate III with benzaldehyde p-​anisidineimine IV providing selectively the required (S)​- or (R)​-​monobactam V.  It is also noticed that the coexistence of III and chiral lithium amides that formed -​in situ- from I,​II is an important factor for the enhancement of the reactivity and enantioselectivity of III.
 

DOI

10.21608/bfsa.2000.66367

Authors

First Name

M.

Last Name

Hussein

MiddleName

A.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt

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First Name

A.

Last Name

El-Shorbagi

MiddleName

A.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt

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Orcid

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First Name

N.

Last Name

Omar

MiddleName

M.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt

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First Name

Z.

Last Name

Farghaly

MiddleName

S.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt

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Orcid

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First Name

Kiyoshi

Last Name

Tomioka

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-

Affiliation

Graduate School of Pharmaceutical Sciences, Department of Synthetic Medicinal Chemistry, Kyoto University, Sakyo-Ku, 606-01, Japan

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Volume

23

Article Issue

2

Related Issue

9998

Issue Date

2000-12-01

Receive Date

2000-03-06

Publish Date

2000-12-31

Page Start

125

Page End

136

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 23_Issue 2_Pages 125-136.pdf

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https://bpsa.journals.ekb.eg/article_66367.html

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https://bpsa.journals.ekb.eg/service?article_code=66367

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

New chiral amine ligands for enantioselective synthesis of certain (S)- and (R)-monobactams

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Article

Created At

22 Jan 2023