Fluoxetine hydrochloride was detd. through charge transfer complexes (CTC) formation with three electron acceptor reagents.  The methods involve the reaction of Fluoxetine as n-​donor with either Chloranil (tetrachloro 1,​4-​benzoquinone)​, tetracyanoethylene (TCNE) or 7,​7,​8,​8-​tetracyanoquinodimethane (TCNQ) as n-​acceptors, to give a stable and highly colored radical anion.  The colored products were quantified spectrophotometrically.  The condition ranges adhering to Beer's law are 0.05-​3.00 mg​/mL.  The molar ratios of the reactants were ascertained.  The different parameters were carefully studied and optimized.  Statistical anal. of the results revealed equal precision and accuracy to the results of the A_max method.  The methods were applied for detn. of Fluoxetine hydrochloride in pure form and in Prozac capsules.