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65967

PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST

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Last updated: 25 Dec 2024

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Abstract

2-Substituted amino-Bi-tl-pyrazotyliquinoxalines 4-11 wereprepared by reacting 2-chloro- 3-hydrazinoquinoxaline 1 with 1,3-dicarbonyl compounds followed by treatment of the resulting 2-chloro-3-(1-pyrazolyl)quinoxlines 2,3 with the proper 2 ° amine. Reacting 1 with pyruvic acid or its ethyl ester afforded the corresponding hydrazone. Upon treating the hydrazone 15 with POCl3, the corresponding [1,2 ,4Jtriazino[4 ,3-a] quinoxallne 17 was achieved. Further, a series of 4-(piperazinyl) tetrazolojl ,5-a]quinoxalines 19-24 was prepared by reacting 1 with nitrous acid followed by treatment of the resulting 4-d,lorotetrazolo[l ,5-a]quinoxalines 18 with ]­substituted piperazlnes. Biological testing of some of the prepared compounds revealed that these compounds may have antidepressant activity and compound 4 has the most pronounced effect

DOI

10.21608/bfsa.2001.65967

Authors

First Name

M.

Last Name

Badran

MiddleName

M.

Affiliation

Departments of 'Organic Chemistry

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Orcid

-

First Name

S.

Last Name

Botros

MiddleName

-

Affiliation

Departments of 'Organic Chemistry

Email

-

City

-

Orcid

-

First Name

A.

Last Name

El-Gendy

MiddleName

A.

Affiliation

Departments of 'Organic Chemistry

Email

-

City

-

Orcid

-

First Name

N.

Last Name

Abdou

MiddleName

A.

Affiliation

Departments of 'Organic Chemistry

Email

-

City

-

Orcid

-

First Name

H.

Last Name

El-Assi

MiddleName

-

Affiliation

Departments of 'Organic Chemistry

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Salem

MiddleName

-

Affiliation

Pharmacology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

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Volume

24

Article Issue

2

Related Issue

9954

Issue Date

2001-12-01

Receive Date

2001-01-04

Publish Date

2001-12-01

Page Start

135

Page End

144

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 24_Issue 2_Pages 135-144.pdf

PDF . 538.2kB

Link

https://bpsa.journals.ekb.eg/article_65967.html

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https://bpsa.journals.ekb.eg/service?article_code=65967

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST

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Article

Created At

22 Jan 2023