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65963

EFFECT OF SOME PLANTS USED IN ARABIC TRADITIONAL MEDICINE ON BLOOD GLUCOSE, CHOLESTEROL AND TRIGLYCERIDES LEVELS OF NORMAL AND STREPTOZOTOCIN-HYPERGLYCEMIC MICE

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Last updated: 04 Jan 2025

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Abstract

The ethanol extracts of three plants used for folkloric treatment of diabetes mellitus in the Middle East: Salvadora persica L (bark and wood), Savine (Juniperus sabina L.) (aerial parts), Asofetida (Ferula foetida L) (oleo-gum-resin) were administered orally in dose 300 mg/kg body weight to normal and streptozotocin (S1Z)-induced diabetic mice. The blood serum glucose, total cholesterol and triglycerides levels were measured spearophotometrically two hours ofter administration of plant extracts. Intraperitoneal administration of S1Z (120 mg/kg body weight) induced hyperglycemia (121.8±10.9 versus 83.5±5.2 in control, p < 0.01), hypercholesterolemia(147.0±12.8 versus 110.1±8.0 in control, p < 0.05), and hypertriglyceridemla (163.3±8.6 versus 98.9±5.4 in control, p < 0.001). Savine extract reduced blood serum glucose level in S1Z-diabetic mice (56. 7±5.0, which is 67.9% of control level, p < 0.001) but not in normal mice. In contrast, total cholesterol serum level was decreased by Savine in normal (108.9±10.3, which is 75.6% of control level, p < 0.05), but not in diabetic animals. Salvadora persica (wood) extract produced hypoglycemia only in normal mice (65.6±6.2, which is 64.5% of control level, p < 0.01). Neither of plant extracts caused significant changes in triglycerides levels. The preliminary phytochemical screening of Savine extract showed the presence of carbohydrates and/or glycosides, sterols and/or triterpenes, volatile oil, tannins and flavonoids as the main active constituents in addition to traces of alkaloids. The results support the use of Savine in patients with diabetes mellitus and indicate its potential usefulness as a cholesterol-lowering drug.

DOI

10.21608/bfsa.2001.65963

Authors

First Name

Z.

Last Name

lbraheim

MiddleName

Z.

Affiliation

Depanmenr of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

N.

Last Name

Boulatova

MiddleName

-

Affiliation

Depanment of Pharmacology, University of Jordan, Amman 11942, Jordan

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Orcid

-

First Name

M.

Last Name

Qato

MiddleName

-

Affiliation

Depanment of Pharmacology, Al-Isra University, Amman, Jordan

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Volume

24

Article Issue

2

Related Issue

9954

Issue Date

2001-12-01

Receive Date

2001-06-26

Publish Date

2001-12-01

Page Start

271

Page End

277

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 24_Issue 2_Pages 271-277.pdf

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https://bpsa.journals.ekb.eg/article_65963.html

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https://bpsa.journals.ekb.eg/service?article_code=65963

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Original Article

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1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF SOME PLANTS USED IN ARABIC TRADITIONAL MEDICINE ON BLOOD GLUCOSE, CHOLESTEROL AND TRIGLYCERIDES LEVELS OF NORMAL AND STREPTOZOTOCIN-HYPERGLYCEMIC MICE

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Article

Created At

22 Jan 2023