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65904

Granule stress relaxation studies as a function of different lubricants

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Last updated: 25 Dec 2024

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Abstract

Effect of the visco-​elastic properties of different lubricants, namely magnesium stearate, talc and precirol, on granule compaction properties was examd. using texture analyzer TAXT21.  Stress relaxation curves of the compacts have been discussed in relation with three parameters (porosity, visco-​elasticity as well as particle size)​.  The study revealed that bonding in compacted granules lubricated with magnesium stearate was higher than those in compacts with other lubricants in study.  It is reasonable that, the large stress relaxation due to magnesium stearate was plastic deformation dependent with no evidence of fragmentation.  While, small stress relaxation due to talc or precirol suggested that, these materials deformed principally by fragmentation.  However, magnesium stearate as tablet lubricant, could be characterized by minimizing the accumulation of stress in the compact, which cause problem of capping, leading to the optimization of tablet manufg.

DOI

10.21608/bfsa.2001.65904

Authors

First Name

F.

Last Name

Ebba

MiddleName

E.

Affiliation

Laboratoire de Pharmacie Galenique Industrielle etde Cosmetologie, Faculte de Phannacie, Universite, de la Mediterranee, Marseille-France

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City

-

Orcid

-

First Name

P.

Last Name

Prinderre

MiddleName

-

Affiliation

Laboratoire de Pharmacie Galenique Industrielle etde Cosmetologie, Faculte de Phannacie, Universite, de la Mediterranee, Marseille-France

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-

City

-

Orcid

-

First Name

S.

Last Name

Omar

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, He/wan University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Ph.

Last Name

Piccerelle

MiddleName

-

Affiliation

Laboratoire de Pharmacie Galenique Industrielle etde Cosmetologie, Faculte de Phannacie, Universite, de la Mediterranee, Marseille-France

Email

-

City

-

Orcid

-

First Name

D.

Last Name

Opota

MiddleName

O.

Affiliation

Laboratoire de Pharmacie Galenique Industrielle etde Cosmetologie, Faculte de Phannacie, Universite, de la Mediterranee, Marseille-France

Email

-

City

-

Orcid

-

First Name

J.

Last Name

Reynier

MiddleName

P.

Affiliation

Laboratoire de Pharmacie Galenique Industrielle etde Cosmetologie, Faculte de Phannacie, Universite, de la Mediterranee, Marseille-France

Email

-

City

-

Orcid

-

First Name

J.

Last Name

Joachim

MiddleName

-

Affiliation

Laboratoire de Pharmacie Galenique Industrielle etde Cosmetologie, Faculte de Phannacie, Universite, de la Mediterranee, Marseille-France

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-

City

-

Orcid

-

Volume

24

Article Issue

2

Related Issue

9954

Issue Date

2001-12-01

Receive Date

2000-06-11

Publish Date

2001-12-01

Page Start

105

Page End

113

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 24_Issue 2_Pages 105-113.pdf

PDF . 615.0kB

Link

https://bpsa.journals.ekb.eg/article_65904.html

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https://bpsa.journals.ekb.eg/service?article_code=65904

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

Granule stress relaxation studies as a function of different lubricants

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Article

Created At

22 Jan 2023