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Determination of critical micelle concentration (CMC) of different pluronics with two different methods

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Last updated: 25 Dec 2024

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Abstract

Pluronics are series of closely related block copolymers of ethylene oxide and propylene oxide and are used primarily in pharmaceutical formulation as emulsifying or solubilizing agents.  In this study, the crit. micelle concn. (CMC) of different pluronics such as L61, L62, L63, L64, L92, F38, and F68 was measured by two different methods.  The first method is the surface tension method (ring method)​; the second one is fluorimetrical method by using DPH (1,​6 di-​Ph hexatriene)​.  It was found that, by increasing the lipophilicity of the block copolymer (increase the propylene oxide moiety) the CMC value increases.  Also, the fluorimetric method is very sensitive, accurate and more reproducible than surface tension method.

DOI

10.21608/bfsa.2002.65701

Authors

First Name

M.

Last Name

El-Badry

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt

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Orcid

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First Name

Rolf

Last Name

Schubert

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-

Affiliation

Department of Pharmaceutical Technology, Institute of Pharmacy, Freiburg University, Freiburg i.BR., Germany

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Volume

25

Article Issue

2

Related Issue

9910

Issue Date

2002-12-01

Receive Date

2002-08-24

Publish Date

2002-12-31

Page Start

201

Page End

205

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_65701.html

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https://bpsa.journals.ekb.eg/service?article_code=65701

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10

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

Determination of critical micelle concentration (CMC) of different pluronics with two different methods

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Article

Created At

22 Jan 2023