Bucco-​adhesive erodible tablets for local delivery of natamycin (NTM) to the oral cavity were prepd. by the direct compression method using different bioadhesive polymers and sol. excipients like mannitol and polyethylene glycol 6000.  Preformulation studies were carried out by using DSC and IR to show that there is no interaction between drug and carrier systems.  The tablets were evaluated for drug content uniformity, friability, hardness, swelling index and surface pH.  The in vitro bio-​adhesive strength and release characteristics were a function of the type of the polymer and also the total compn. of the tablets.  In vivo evaluation of placebo bucco-​adhesive tablets revealed adequate comfort, taste and non-​irritancy during the period of the study.  The bucco-​adhesive tablets eroded completely leaving no exhausting device to be removed.  None of the volunteers reported severe dry mouth, severe salivation or heaviness at the place of attachment.  The selected formulation was able to maintain the salivary concn. of NTM above the MIC against Candida albicans for up to 6 h.