Beta
65408

PREPARATION AND EVALUATION OF NAPROXEN ADSORBATE AS AN ATTEMPT TO IMPROVE DRUG DISSOLUTION CHARACTERISTICS

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

-

Abstract

Naproxen is a nonsteroidal anti-inflammatory drug which shows variable absorption and bioavailability due to its poor solubility. In this study we aimed to improve the dissolution rate of the drug by solvent deposition onto certain adsorbents including porous silica, Avicel and Bentonite. Physical mixtures of naproxen with the investigated adsorbents were also prepared. The molecular behavior of naproxen in the investigated systems were studied using infrared absorption spectra, differential scanning calorimetry and X-ray diffraction analysis. The dissolution rate of the drug was also investigated. The obtained results indicated that naproxen was transformed to the amorphous state in case of mixtures loaded with porous silica. This transformation resulted in a significant enhancement of the dissolution rates of the drug. In addition, it was noticed that, the drug: adsorbents weight ratio of the prepared mixtures influenced the drug dissolution rate enhancement. Accordingly, it can be concluded that, by increasing the weight ratio of the used adsorbent in the mixture, the larger the enhancement in the dissolution rate of naproxen will be obtained.

DOI

10.21608/bfsa.2004.65408

Authors

First Name

Ahmed

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University at Assiut, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

K.

Last Name

Saleh

MiddleName

I.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University at Assiut, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Khalaf

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University at Assiut, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

27

Article Issue

1

Related Issue

9857

Issue Date

2004-06-01

Receive Date

2004-02-26

Publish Date

2004-06-30

Page Start

53

Page End

62

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_65408.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=65408

Order

6

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF NAPROXEN ADSORBATE AS AN ATTEMPT TO IMPROVE DRUG DISSOLUTION CHARACTERISTICS

Details

Type

Article

Created At

22 Jan 2023