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65398

SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANALGESIC AND ANTI-INFLAMMATORY EFFECTS

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Last updated: 04 Jan 2025

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Abstract

3-N-(4`-Hydroxy-3`-substituted phenyl)carbamoyl-1-methylpyridinium iodides (compds. 5b-j) and 3-carbamoyl-1-(N-(4`-hydroxy- 3`-substituted phenyl)carbamoyl) methyl pyridinium chlorides (compds. 7a-j) were synthesised and some of them were tested for their analgesic and antiinflammatory activities by hot plate test and carageenin-induced hind paw edema model, respectively. Compound 5b revealed the most potent analgesic and anti-inflammatory activities in comparison to sulfasalazine (SASP) and 5-ASA. In addition, ulcerogenicity, LD50, in-vivo and in vitro cleavage and pH stability of compound 5b were also determined.

DOI

10.21608/bfsa.2005.65398

Authors

First Name

H.

Last Name

Abdu-Allah

MiddleName

H. M.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut-71526, Egypt

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First Name

S.

Last Name

Abdel-Moty

MiddleName

G.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut-71526, Egypt

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Orcid

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First Name

A.

Last Name

El-Shorbagi

MiddleName

A.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut-71526, Egypt

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Orcid

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First Name

A.

Last Name

Abdel-Alim

MiddleName

M.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut-71526, Egypt

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Volume

28

Article Issue

2

Related Issue

9840

Issue Date

2005-12-01

Receive Date

2005-04-11

Publish Date

2005-12-31

Page Start

237

Page End

253

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 28_Issue 2_Pages 237-253.pdf

PDF . 380.5kB

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https://bpsa.journals.ekb.eg/article_65398.html

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https://bpsa.journals.ekb.eg/service?article_code=65398

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Original Article

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1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANALGESIC AND ANTI-INFLAMMATORY EFFECTS

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Created At

22 Jan 2023