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65215

PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATIONS OF FLACOURTIA CATAPHRACTA ROXB. CULTIVATED IN EGYPT

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Last updated: 25 Dec 2024

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Abstract

The concentrated 70% ethanolic extracts of the air-dried powdered leaves and stem bark of Flacourtia cataphracta were subjected separately to solvent fractionation by partitioning using n-hexane, chloroform and ethyl acetate respectively. Each concentrated fraction was subjected to TLC followed by isolation, purification and identification of the available constituents. Fourteen compounds were isolated and identified by different spectral tools (UV, IR, 1H-NMR, 13C-NMR, MS) and comparison with corresponding literature data.  -amyrin (1),  -amyrin (2), and a mixture of  -sitosterol and stigmasterol (3) were isolated from nhexane fraction of both leaves and stem bark. 2-Oxo-18benzolyloxy-13(16), 14-tetrahydrocleroda-3-ene (4), 3 -acetoxyD:A friedo oleanan-27,16  -lactone (5), 4,4'-dihydroxychalcone (6), apigenin (7) and kampferol (8) were isolated from chloroform fraction of the stem bark.  -Sitosterol-3-O -D-glucoside (9), 5-Ocaffeoylquinic acid (10) were isolated from the ethyl acetate fraction of the leaves in addition to vanillin (11), benzoic acid (12), protocatechuic acid (13) and flacourtin (14) from the ethyl acetate fraction of the stem bark. The different leaf extracts were subjected to biological study which revealed that n-hexane, ethyl acetate and methanol fractions of Flacourtia cataphracta Roxb. are safe to be used as antidiarrheal, anti-inflammatory and antipyretic drug.

DOI

10.21608/bfsa.2006.65215

Authors

First Name

Hanaa

Last Name

Sayed

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Mahmoud

Last Name

Mohamed

MiddleName

H.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

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City

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Orcid

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First Name

Faten

Last Name

Darwish

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

Ahmed

Last Name

Mohamed

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

Email

a.abdelmawla@aun.edu.eg

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-

Orcid

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Volume

29

Article Issue

2

Related Issue

9838

Issue Date

2006-12-01

Receive Date

2006-07-31

Publish Date

2006-12-01

Page Start

371

Page End

387

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_65215.html

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https://bpsa.journals.ekb.eg/service?article_code=65215

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATIONS OF FLACOURTIA CATAPHRACTA ROXB. CULTIVATED IN EGYPT

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Article

Created At

22 Jan 2023