The alcoholic extracts of the leaves and bark of Grevillea robusta A.Cunn cultivated in Egypt were subjected to preliminary anti-inflammatory screening. The results showed that, the alcoholic extracts showed a significant anti-inflammatory activity using carrageenan-induced edema. The alcoholic and aqueous extracts of the bark were tested as anti-HIV-1 protease, where they showed a moderate HIV-1 protease (1 PR) inhibitory activity at conc. 200 µg/ml. The ethyl acetate fraction of the bark showed a significant HIV-RT inhibitory activity, the n-butanol fraction showed a moderate activity, while the chloroform fraction showed no activity at conc. 200 µg/ml. On the other hand the chloroform and ethyl acetate fractions of the fruit showed a weak HIV-RT inhibitory activity. From the chloroform-soluble fraction of the total alcohol extract of the bark 2,6-dimethoxy-1,4-benzoquinone,  -sitosterol, 4-(1-hydroxy ethyl) anisol, robustol and  -sitosterol glucoside were isolated. Four phenolic glycosides were isolated from the nbutanol-soluble fraction of the bark and identified as arbutin, arbutin 2'-O -apiofuranoside, 4-hydroxyphenethyl alcohol 8-O apiofuranosyl(1''→2') -glucopyranoside and 4-O-trans-pcoumaroyl{  -glucopyranoside}8-O -apiofuranosyl-(1''→ 6')}-O -glucopyranosyl. The identification of the isolated compounds was carried out using different methods including physical, chemical and spectral analysis.