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65196

EFFECT OF POROUS SILICA AS A DRUG CARRIER ON THE RELEASE RATE OF NAPROXEN FROM EMULGEL

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Last updated: 04 Jan 2025

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Abstract

Naproxen was loaded on Florite R (porous silica) by solvent deposition technique. The physical and loaded drug mixtures were examined by x-ray diffractometry and differential scanning calorimetry (DSC). The in-vitro dissolution of the drug from loaded and physical mixture was studied. The best formula which contains (1:2) drug:adsorbent ratio was formulated into emulgel using different gelling agents. The in-vitro release of naproxen from the selected emulgel bases was carried out. X-ray and DSC results revealed that the drug was changed from the crystalline to amorphous state depending on drug to carrier ratio since the complete transformation was obtained from the loaded mixture containing (1:2) drug:Florite R ratio. Transformation of the drug to the amorphous state in the loaded mixture led to an enhancement of both drug dissolution and in-vitro release rates.

DOI

10.21608/bfsa.2006.65196

Authors

First Name

Ahmed

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

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Orcid

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First Name

K.

Last Name

Saleh

MiddleName

I.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

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City

-

Orcid

-

First Name

M.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Khalaf

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

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-

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-

Orcid

-

Volume

29

Article Issue

2

Related Issue

9838

Issue Date

2006-12-01

Receive Date

2006-03-06

Publish Date

2006-12-31

Page Start

224

Page End

235

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_65196.html

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https://bpsa.journals.ekb.eg/service?article_code=65196

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF POROUS SILICA AS A DRUG CARRIER ON THE RELEASE RATE OF NAPROXEN FROM EMULGEL

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Article

Created At

22 Jan 2023