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147033

PATTERN OF CANDIDA URINARY TRACT INFECTIONS AMONG CANCER PATIENTS IN SOUTH EGYPT CANCER INSTITUTE

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Last updated: 25 Dec 2024

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Abstract

The last decade has seen the sustained medical importance of opportunistic infections due to different Candida species mainly because of the worldwide increasing in the number of immunocompromised patients, who are highly susceptible to opportunistic infections. Urine samples were collected from 106 cancer patients in South Egypt Cancer Institute (SECI) that were cultured on Sabouraud dex­trose agar media for isolation of Candida species. After Gram staining subculture was done on Hicrome Candida Differential Agar media. Results of the previous media were compared with those obtained with API 20C AUX yeast identification kits. The study revealed an overall isolation rate of Candida species among urinary tract infections was 20.8% (22/106). Single type of Candida species was isolated from cancer patients with candiduria 16/22 (72.7%) while six Patients had mixed species. Candida albicans was the most frequent species isolated responsible for fungal urinary tract infections 27.3% (6/22). Non-Candida albicans species including Candida tropicalis (13.6%), Candida glabrata (13.6%), Candida stellatoides (9.1%), Candida krusei (4.5%) and Candida guilliermondii (4.5%) were also isolated. Candida albicans, Candida stellatoides and Candida guilliermondii could not be identified on chrom agar as all the isolates gave similar green colonies. Also Candida glabrata and Candida krusei could not be identified on chrom agar as they gave similar white colonies. Chrom agar identifies all Candida tropicalis as the isolates gave the typical pattern of purple to blue colonies. Candida albicans identified on Czapek Dox Agar media as they produced chlamydospores. The results of API 20C AUX were in 100% agreement with the results of Chrom agar in identification of Candida tropicalis. E- test on (SDA) was found to be an accurate method for antifungal susceptibility as it was compared with the reference broth microdilution method recommended by National Committee for Clinical Laboratory Standards (NCCLs). For fluconazole the E-test demonstrated 94.1% agreement for all candida species.

DOI

10.21608/bfsa.2010.147033

Authors

First Name

Nabila

Last Name

M Rashwan

MiddleName

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Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assuit University

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Orcid

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First Name

Abdel-Khalk

Last Name

A Mohamed

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assuit University

Email

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City

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Orcid

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First Name

Salwa

Last Name

Saif El-Deen

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assuit University

Email

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City

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Orcid

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First Name

Entsar

Last Name

H Ahmed

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assuit University

Email

-

City

-

Orcid

-

First Name

Shaymaa

Last Name

Abdalla Ismail

MiddleName

-

Affiliation

South Egypt Cancer Institute, Assuit University

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Orcid

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Volume

33

Article Issue

2

Related Issue

9780

Issue Date

2010-12-01

Receive Date

2010-09-20

Publish Date

2010-12-31

Page Start

121

Page End

130

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 33_Issue 2_Pages 121-130.pdf

PDF . 510.0kB

Link

https://bpsa.journals.ekb.eg/article_147033.html

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https://bpsa.journals.ekb.eg/service?article_code=147033

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3

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PATTERN OF CANDIDA URINARY TRACT INFECTIONS AMONG CANCER PATIENTS IN SOUTH EGYPT CANCER INSTITUTE

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Article

Created At

22 Jan 2023