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147025

MUCOADHESIVE BUCCAL PATCHES OF LORNOXICAM: I- DEVELOPMENT AND IN-VITRO CHARACTERIZATION

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Last updated: 25 Dec 2024

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Abstract

Lornoxicam as a non-steroidal anti-inflammatory drug (NSAID) has the same side effects of this group if taken orally (GIT, renal, and hepatic disorders). Lornoxicam and its metabolites bind extensively to plasma albumin (99%), beside that, it has a relatively short half-life (3 to 5 hrs). The drug was formulated in mucoadhesive buccal patches using different polymers including, hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), hydroxypropylmethyl cellulose (HPMC), chitosan, polyvinyl alcohol (PVA), gelatin, sodium alginate and sodium carboxymethyl cellulose (Na CMC). The physical characteristics of the formulated patches as mass uniformity, patch thickness, surface pH, folding endurance, swelling, residence time as well as mucoadhesion (in-vitro and ex-vivo mucoadhesion force) were evaluated. The in-vitro release of the drug from the formulated patches was studied using the USP dissolution apparatus, and the results indicated that HEC, HPC and chitosan showed the lowest drug release (70%, 76%, and 81%, respectively) while gelatin, sodium alginate and Na CMC gave the highest release (nearly 100%). Permeation of lornoxicam formulated in different patches through rabbit buccal mucosa was also studied and the results showed that gelatin and chitosan patches resulted in the highest drug permeation. Kinetics of drug release from the different patches was found to follow zero order or diffusion kinetics.

DOI

10.21608/bfsa.2010.147025

Authors

First Name

Fawzia

Last Name

Habib

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

Maha

Last Name

Abdel Azeem

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

mahashawkat@yahoo.com

City

-

Orcid

-

First Name

Gihan

Last Name

Fetih

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Safwat

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

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Orcid

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Volume

33

Article Issue

1

Related Issue

9726

Issue Date

2010-06-01

Receive Date

2010-05-04

Publish Date

2010-06-30

Page Start

59

Page End

68

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 33_Issue 1_Pages 59-68.pdf

PDF . 355.9kB

Link

https://bpsa.journals.ekb.eg/article_147025.html

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https://bpsa.journals.ekb.eg/service?article_code=147025

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

MUCOADHESIVE BUCCAL PATCHES OF LORNOXICAM: I- DEVELOPMENT AND IN-VITRO CHARACTERIZATION

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Article

Created At

22 Jan 2023