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147021

PREPARATION AND EVALUATION OF DICLOFENAC SODIUM–CELLULOSE ACETATE MICROCAPSULES USING SOLVENT EVAPORATION TECHNIQUE

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Last updated: 25 Dec 2024

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Abstract

The aim of this study was the preparation of diclofenac sodium microcapsules using cellulose acetate as a polymer and polyvinyl acohol as an emulsifying agent by solvent evaporation technique. Preliminary experiments were carried out to determine practically the volume range of both the external phase, the internal organic phase, the concentration range of emulsifier and the drug to polymer ratio. The prepared microcapsules were evaluated for their morphology and surface structure, average particle size, yield, drug loading efficiency, and their release pattern. The results of these trials revealed that diclofenac sodium–cellulose acetate microcapsules were successfully prepared applying the solvent evaporation technique. The characteristics of the produced microcapsules were highly affected by the different formulation parameters. Changing the polymer content didn't affect the morphology of the produced microcapsules. The microcapsules were discrete, spherical and freely flowing. The increase in the polymer amount increased the mean particle size and decreased the yield of the microcapsules due to the increase in the internal phase viscosity. The drug loading efficiency was significantly increased with the increase in methylene chloride–acetone volume. The condensed monolayer of polyvinyl alcohol was not achieved at concentrations below 0.5%. Above this concentration, the increase in polyvinyl alcohol content decreased both the mean particle diameter and the percentage yield of the microcapsules. The release of diclofenac sodium from cellulose acetate microcapsules was pH dependent. The drug was released faster in the alkaline medium compared to acidic medium

DOI

10.21608/bfsa.2010.147021

Authors

First Name

Mahmoud

Last Name

M. Ahmed

MiddleName

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Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt

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First Name

Sayed

Last Name

H. Auda

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-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt

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-

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Orcid

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First Name

S.

Last Name

Abd El-Rasoul

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt

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Orcid

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First Name

K.

Last Name

I. Saleh

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-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt

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Orcid

-

First Name

G.

Last Name

M. Zayed

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Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt

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Volume

33

Article Issue

1

Related Issue

9726

Issue Date

2010-06-01

Receive Date

2010-04-12

Publish Date

2010-06-30

Page Start

43

Page End

49

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 33_Issue 1_Pages 43-49.pdf

PDF . 513.2kB

Link

https://bpsa.journals.ekb.eg/article_147021.html

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https://bpsa.journals.ekb.eg/service?article_code=147021

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF DICLOFENAC SODIUM–CELLULOSE ACETATE MICROCAPSULES USING SOLVENT EVAPORATION TECHNIQUE

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Article

Created At

22 Jan 2023