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FORMULATION AND PHYSICOCHEMICAL CHARACTERIZATION OF PIROXICAM CONTAINING POLYMER FILMS

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Last updated: 25 Dec 2024

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Abstract

Piroxicam is a potent nonsteroidal anti-inflammatory drug associated with many side effects when taken orally. An attention was paid in this work to formulate and characterize piroxicam containing polymer films for dermal use. The used polymers were Eudragit types namely Eudragit RL100, RS100, L100 and Eudragit S100. In this study, medicated films consisting of drug and carrier were prepared. The carrier consisted of one or two polymers. The physicochemical characterization was done by IR spectroscopy, DSC and X-Ray diffractometry for both piroxicam polymeric films and their corresponding physical mixtures as well as the untreated drug and polymer powders to investigate the drug polymer interaction. The results indicate presence of molecular interactions between piroxicam and both Eudragit L100 and Eudragit S100 and no interactions were found between piroxicam and Eudragit RL100 or Eudragit RS100. In-vitro drug release from Eudragit films was studied. It is found that the drug release from hydrophilic polymers is faster than that from hydrophobic ones.  

DOI

10.21608/bfsa.2010.147018

Authors

First Name

Sayed

Last Name

H. Auda

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Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt

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First Name

Mahmoud

Last Name

M. Ahmed

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Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Abd El-Rasoul

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Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt

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Orcid

-

First Name

K.

Last Name

I. Saleh

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-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt

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Volume

33

Article Issue

1

Related Issue

9726

Issue Date

2010-06-01

Receive Date

2010-04-12

Publish Date

2010-06-30

Page Start

33

Page End

42

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 33_Issue 1_Pages 33-42.pdf

PDF . 668.5kB

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https://bpsa.journals.ekb.eg/article_147018.html

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https://bpsa.journals.ekb.eg/service?article_code=147018

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND PHYSICOCHEMICAL CHARACTERIZATION OF PIROXICAM CONTAINING POLYMER FILMS

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Article

Created At

22 Jan 2023