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147010

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS CONTAINING ANTIOXIDANTS

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Last updated: 25 Dec 2024

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Abstract

Deficiency in nutrients especially antioxidants play an important role in the pathogenesis of acquired immuno-deficiency syndrome (AIDS). Antioxidants; vitamin A, vitamin C, vitamin E, zinc and selenium are available in market as capsules. The release rate is very fast followed by fast elimination. It is necessary to prolong the residence time of antioxidants. Sustained release tablet formulation was designed and evaluated on small scale and on large scale preparations. Low attention has been discuss the use of sustained release formula in treatment of AIDS. Sustained release tablet formulation was designed and evaluated on small scale and on large scale preparations. The formulated tablets contained beta-carotene, vitamin C, tocopherol acetate, selenium, yeast and zinc pidolate. Vitamin C was chosen as tracer for detection and evaluation of tablet dosage form. Vitamin C was found to be stable in 0.1 N HCl (pH 1.2) along 8 hrs at 37°C. The formulated tablets passed the pharmacopeial requirements for all tablet tests. The formulated tablets showed sustained release characteristics of vitamin C as a tracer, within 8 hrs.
 

DOI

10.21608/bfsa.2010.147010

Authors

First Name

J.

Last Name

Cantoni

MiddleName

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Affiliation

Department of Pharmacy, Lapeyronie Hospital, Montpellier, France

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Orcid

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First Name

S.

Last Name

Shawky Tous*

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

B.

Last Name

Bataille

MiddleName

-

Affiliation

Department of Pharmacy, Lapeyronie Hospital, Montpellier, France

Email

-

City

-

Orcid

-

First Name

P.

Last Name

Prinderre

MiddleName

-

Affiliation

Department of Galenic Pharmacy and Biopharmacy, Faculty of Pharmacy, Marseille, France

Email

-

City

-

Orcid

-

First Name

J.

Last Name

P. Reynier

MiddleName

-

Affiliation

Department of Galenic Pharmacy and Biopharmacy, Faculty of Pharmacy, Marseille, France

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-

City

-

Orcid

-

First Name

S.

Last Name

Hansel-Esteller

MiddleName

-

Affiliation

Department of Pharmacy, Lapeyronie Hospital, Montpellier, France

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-

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-

Orcid

-

Volume

33

Article Issue

1

Related Issue

9726

Issue Date

2010-06-01

Receive Date

2010-03-25

Publish Date

2010-06-30

Page Start

9

Page End

18

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 33_Issue 1_Pages 9-18.pdf

PDF . 348.6kB

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https://bpsa.journals.ekb.eg/article_147010.html

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https://bpsa.journals.ekb.eg/service?article_code=147010

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS CONTAINING ANTIOXIDANTS

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Article

Created At

22 Jan 2023