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156598

CONTROLLED-RELEASE PREDNISOLONE POLY (DL-LACTIDE) MICROSPHERES: IMPACT OF FORMULATION PARAMETERS, CHARACTERIZATION AND RELEASE MECHANISM

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Last updated: 04 Jan 2025

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Abstract

The steroidal drug prednisolone was encapsulated into microspheres using the biodegradable polymer poly (DL-lactide) using emulsion-solvent evaporation method. The produced microspheres were characterized using scanning electron microscopy, X-ray diffractometery, FT-IR spectroscopy, DSC, and laser light diffraction. The morphology, particle size distribution, encapsulation efficiency (EE%), and drug release showed marked dependence upon formulation parameters viz. initial polymer concentration, surfactant concentration, drug-to-polymer ratio, and volume of the external aqueous phase. The effect of the addition of hydrophilic additives such as PVP or PEG 8000 was also investigated. The encapsulation efficiency percent and the mean particle size were increased by increasing the initial polymer concentration and drug polymer ratio. On the other hand, increasing the surfactant concentration resulted in decreasing the mean particle size and increasing the drug release from the microspheres. The probable mechanism of drug release was estimated and found to be via diffusion through channels and/or pores present within the polymeric matrix. Release data of almost all formulae fitted Higuchi's planar model better than spherical model. This finding could be due to the small extent of drug release (~ 40%), or the presence of a large fraction of the encapsulated drug nearby the surface of the microspheres.

DOI

10.21608/bfsa.2008.156598

Authors

First Name

Khaled

Last Name

A. Khaled

MiddleName

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt

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Orcid

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First Name

Hatem

Last Name

A. Sarhan

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt

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Orcid

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First Name

Mohamed

Last Name

A. Ibrahim

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

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City

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Orcid

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First Name

Youssef

Last Name

W. Naguib

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt

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Volume

31

Article Issue

1

Related Issue

9715

Issue Date

2008-06-01

Receive Date

2008-03-17

Publish Date

2008-06-30

Page Start

49

Page End

67

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 31_Issue 1_Pages 49-67.pdf

PDF . 537.5kB

Link

https://bpsa.journals.ekb.eg/article_156598.html

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https://bpsa.journals.ekb.eg/service?article_code=156598

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CONTROLLED-RELEASE PREDNISOLONE POLY (DL-LACTIDE) MICROSPHERES: IMPACT OF FORMULATION PARAMETERS, CHARACTERIZATION AND RELEASE MECHANISM

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Article

Created At

22 Jan 2023