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64591

BUCCOADHESIVE TABLETS FOR DELIVERY OF VERAPAMIL HCl: DESIGN, IN-VITRO ANALYSIS AND IN-VIVO EVALUATION

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Last updated: 25 Dec 2024

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Abstract

Buccoadhesive controlled release verapamil HCl tablets have been prepared using mucoadhesive polymers namely; sodium alginate (Na Alg), xanthan gum (XG) and gum tragacanth (GT) either alone or in combination in different ratios 2:8, 8:2, 4:6 and 6:4. The prepared tablets were evaluated for their weight variation, thickness, hardness, friability and dissolution, content uniformity, swelling index, in-vitro adhesion, in-vitro drug release and invivo hypertension study. Tablets containing XG showed the highest swelling index and bioadhesive force. The maximum cumulative % released (100%) was observed in F7, F10 and F11 due to high percent of Na alg. The kinetics studies show that the release follows zero order kinetics except F1 that it obeyes a diffusion model. The buccoadhesive verapamil HCl tablet had suggested being promising for the transmucosal delivery of verapamil HCl and allowing a controlled drug delivery for 6 hrs.

DOI

10.21608/bfsa.2012.64591

Authors

First Name

Fakhr

Last Name

Ghazy

MiddleName

El Din S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

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Orcid

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First Name

Hanan

Last Name

El-Nahas

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

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Orcid

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First Name

Mohamed

Last Name

Gad

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

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City

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Orcid

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First Name

Noura

Last Name

Eissa

MiddleName

G.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

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-

City

-

Orcid

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Volume

35

Article Issue

1

Related Issue

9673

Issue Date

2012-06-01

Receive Date

2012-01-24

Publish Date

2012-06-30

Page Start

17

Page End

25

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_64591.html

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https://bpsa.journals.ekb.eg/service?article_code=64591

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2

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

BUCCOADHESIVE TABLETS FOR DELIVERY OF VERAPAMIL HCl: DESIGN, IN-VITRO ANALYSIS AND IN-VIVO EVALUATION

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Article

Created At

22 Jan 2023